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MEK/RAF-IN-1

CAT: 0931-T200267-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200267-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Kras, Ras, Raf, MEK
Related Pathways
MAPK
Bioactivity
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.
Molecular Formula
C28H29F3N6O5S
Molecular Weight
618.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-162873MEK/RAF-IN-1
TBI4112-25MGAvutometinib, Dual MEK/RAF inhibitor
C0039-01C-raf 1 (Raf, Raf-1) discontinued
323554-01MEK-1
MBS5766266MEK-IN-1
R0495-09HRaf (Raf-1, c-Raf) discontinued
C0039-01-HRPC-raf 1 (Raf, Raf-1) (HRP) discontinued
C0039-01-FITCC-raf 1 (Raf, Raf-1) (FITC) discontinued
C0039-01-BiotinC-raf 1 (Raf, Raf-1) (Biotin) discontinued
C0039-01-PEC-raf 1 (Raf, Raf-1) (PE) discontinued

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