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PARP1-IN-27

CAT: 0931-T200224-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200224-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, PARP, Reactive Oxygen Species
Related Pathways
Chromatin/Epigenetic, Metabolism, DNA Damage/DNA Repair, Immunology/Inflammation, NF-κB, Apoptosis
Bioactivity
PARP1-IN-27 (Compound 9B) serves as an inhibitor of both PARP1 and PARP2, exhibiting IC 50 values of 2.53 nM and 6.45 nM, respectively, in SUM149PT cells. This compound effectively suppresses the proliferation of BRCA-mutated cancer cell lines such as SUM149PT, HCC1937, and Capan-1, with respective IC 50 values of 0.62, 1.91, and 4.26 μM. Additionally, PARP1-IN-27 exacerbates DNA double-strand breaks, enhances ROS production, causes G2/M phase cell cycle arrest, and triggers apoptosis in SUM149PT cells.
Molecular Formula
C17H12FNO4
Molecular Weight
313.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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