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PF-7006

CAT: 0931-T200142-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T200142-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2771955-09-8
Target
Kinesin|||Apoptosis
Related Pathways
Apoptosis|||Cytoskeletal Signaling
Bioactivity
PF-7006, an Mps1 kinase inhibitor, exhibits a Ki value of 0.27 nM and an IC50 value of 2.5 nM. It disrupts cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reduces histone H3 levels, and shortens the duration of mitosis, thereby inducing apoptosis (Apoptosis) in cancer cells. When used in combination with Palbociclib, the tolerance of cancer cells to PF-7006 is enhanced. PF-7006 is applicable for research on breast cancer.
Smiles
N#CC1=CNC2=NC(=NC(NC3CCOCC3)=C12)NC4=CC=C(N=C4C)N5CCOCC5
Molecular Formula
C22H26N8O2
Molecular Weight
434.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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