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PCSK9-IN-30

CAT: 0931-T200082-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200082-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
PCSK9-IN-30 (Compound 3f), a PCSK9 inhibitor, effectively targets a cryptic binding groove on PCSK9, thereby preventing PCSK9 from associating with the low-density lipoprotein receptor (LDLR) (IC 50 = 537 nM) . This inhibition aids in the restoration of low-density lipoprotein (LDL) uptake by liver cells and significantly reduces plasma cholesterol levels. Demonstrating good bioavailability in mice, PCSK9-IN-30 holds potential for research within cardiovascular disease contexts.
Molecular Formula
C30H33N5O2
Molecular Weight
495.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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