Recombinant Human SAAprotein

• Background:

  Serum amyloid A (SAA) proteins are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma. Different isoforms of SAA are expressed constitutively (constitutive SAAs) at different levels or in response to inflammatory stimuli (acute phase SAAs) .The conservation of these proteins throughout invertebrates and vertebrates suggests that SAAs play a highly essential role in all animals. Serum amyloid A (SAA) is also an acute phase marker that responds rapidly. It has been suggested that SAA levels correlate better with disease activity in early inflammatory joint disease than do ESR and CRP. Although largely produced by hepatocytes, more recent studies show that SAA is produced by adipocytes as well, and its serum concentration is associated with body mass index.

• Description:

  Recombinant human serum amyloid A protein with molecular weight of 30 kDa.

• Synonyms:

  Amyloid A, serum, Amyloid fibril protein AA, Amyloid protein A, PIG4, SAA, SAA2, Serum amyloid A protein, serum amyloid A-1 protein, serum amyloid A1, TP53I4, Tumor protein p53 inducible protein 4.

• Source:

  E. Coli

• Applications:

  Western Blot, WB; ELISA

• Purity:

  >85%by SDS-PAGE

• Buffer:

  Each vial contains 50 mM Tris, 300mM NaCl, 1 mM DTT, 1 mM EDTA & 0.2% PMSF, pH8.0.

• References & Citations:

  Manley PN, Ancsin JB, Kisilevsky R (2006) . "Rapid recycling of cholesterol: the joint biologic role of C-reactive protein and serum amyloid A". Med. Hypotheses. 66 (4) : 784–92. Pincus MR, McPherson RA, Henry JB (2007) . Henry's Clinical Diagnosis and Management by Laboratory Methods. Saunders Elsevier.

• Storage Conditions:

  Shipat 4°C. Upon receipt, aliquot and store at -20°C or -40°C for long term. Avoid repeated freeze and thaw cycles.

• Formulation:

  Liquid