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Recombinant Human IGFBP1Protein

CAT: 1510-BRP1114-01Size: 100 μgDry Ice: NoHazardous: No
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CAT#:1510-BRP1114-01Size:100 μg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene. IGFBP1 expression after treatment of E2 was examined in a HepG2 hepatoma cell line. Meanwhile, both mRNA and protein expressions of IGFBP1 were elevated in placenta and liver tissues. Furthermore, the level of IGFBP1 in the HepG2 cell line was elevated by the treatment of E2, whereas this effect was blocked by estrogen receptor antagonist ICI 182780. Among clinical variables, the IGFBP1 level was correlated with HDL-C. IGFBP1 alone (cutoff 20.86 ng/ml) demonstrated a sensitivity of 0.448 and specificity of 0.933 in predicting CAD. Combination of IGFBP1 and HDL-C had a sensitivity of 0.821 and specificity of 0.800 in predicting CAD. Conclusions. Circulating IGFBP1 level positively correlated with the severity of CAD. IGFBP1, when combined with HDL-C, might be useful in screening for high risk CAD patients.
Description
Recombinant human Insulin Like Growth Factor Binding 1 protein with molecular weight of 31 kDa.
Synonyms
Insulin-like Growth Factor Binding Protein 1, IGFBP-1, AFBP, Alpha pregnancy associated endometrial globulin, Amniotic fluid binding protein, Binding protein 25, Binding protein 26, Binding protein 28, Growth hormone independent binding protein, hIGFBP 1, hIGFBP1, IBP 1, IBP1, IGF binding protein 1, IGF BP25, IGFBP 1, Placental protein 12, PP12
Source
E. coli
Applications
SDS-PAGE; ELISA
Purity
>90% by SDS-PAGE
Buffer
Each vial contains 10 mM Tris-HCl pH 9.0.
References & Citations
1.Zheng W, Lai Y, Jin P, Gu W, Zhou Q, Wu X. Association of Circulating IGFBP1 Level with the Severity of Coronary Artery Lesions in Patients with Unstable Angina. Dis Markers. 2017,2017:1917291. Jin M, Lv PP, Yu TT, Shen JM, Feng C, Huang HF. IGFBP1 Involved in the Decreased Birth Weight Due to Fetal High Estrogen Exposure in Mice. Biol Reprod. 2016 Nov,95 (5) :96. Epub 2016 Sep 14..
Storage Conditions
Shipat 4°C. Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Liquid

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