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Romaciclib (hydrochloride)

CAT: 0804-HY-111388B-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111388B-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEL120-34A hydrochloride is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity.
CAS Number
1609452-30-3
Product Name Alternative
SEL120-34A (hydrochloride)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sel120-34a-hydrochloride.html
Purity
99.98
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC1=C(Br)C(Br)=C2C3=C1N=C(N4CCNCC4)N3CCC2.Cl
Molecular Formula
C15H18Br2N4.xHCl
Precautions
H315, H319, H335
References & Citations
[1]Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8 (20) :33779-33795.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CDK19; CDK8; CDK9
Citation 01
Adv Sci (Weinh) . 2025 Nov 19:e18346.|bioRxiv. 2025 January 24.|Cell. 2021 Apr 15;184 (8) :2167-2182.e22.|Friedrich-Alexander-Universität Erlangen-Nürnberg. 2023 Jun 23.|Nat Commun. 2024 Mar 19;15 (1) :2198.|Nat Commun. 2019 Oct 18;10 (1) :4741. |Int J Mol Sci. 2022 Feb 24;23 (5) :2493.

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