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Romaciclib (monohydrochloride)

CAT: 0804-HY-111388A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111388A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726[1]. Has anti-tumor activity[1].
CAS Number
2443816-41-7
Product Name Alternative
SEL120-34A (monohydrochloride)
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SEL120-34A_monohydrochloride.html
Purity
99.29
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
Smiles
CC1=C2C3=C(C(Br)=C1Br)CCCN3C(N4CCNCC4)=N2.Cl
Molecular Formula
C15H19Br2ClN4
Molecular Weight
450.60
References & Citations
[1]Rzymski T, et al. SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains. Oncotarget. 2017 May 16;8 (20) :33779-33795.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK19; CDK8; CDK9
Citation 01
Int J Mol Sci. 2022 Feb 24;23 (5) :2493.|Adv Sci (Weinh) . 2025 Nov 19:e18346.|bioRxiv. 2025 January 24.|Cell. 2021 Apr 15;184 (8) :2167-2182.e22.|Friedrich-Alexander-Universität Erlangen-Nürnberg. 2023 Jun 23.|Nat Commun. 2024 Mar 19;15 (1) :2198.|Nat Commun. 2019 Oct 18;10 (1) :4741.

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