Recombinant human Complement Factor B protein

CAT: 0112-ATGP3540-050Size: 50 µgDry Ice: NoHazardous: No
CAT#:0112-ATGP3540-050Size:50 µg
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Description
CFB, also known as complement factor B, is a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. Recombinant human CFB protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
Complement factor B, CFB, AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
27.3 kDa (245aa)
Additionnal Information
Complement Factor B, Complement factor B, CFB, AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2, ATGP3540-10 µg, ATGP3540-20 µg, ATGP3540-50 µg, ATGP3540-100 µg, ATGP3540-250 µg, ATGP3540-500 µg, ATGP3540-1 mg, ATGP3540-10, ATGP3540-20, ATGP3540-50, ATGP3540-100, ATGP3540-250, ATGP3540-500, ATGP3540-1
References & Citations
Francis PJ., et al. (2009) J Med Genet. 46:300-307.; ; Schwaeble W., et al (1993) . Immunobiology 188:221-232.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001701.2
Uniprot Accession Number
P00751
Species
Human
N Terminal Sequence
Ala
AA Sequence
TPWSL ARPQGSCSLE GVEIKGGSFR LLQEGQALEY VCPSGFYPYP VQTRTCRSTG SWSTLKTQDQ KTVRKAECRA IHCPRPHDFE NGEYWPRSPY YNVSDEISFH CYDGYTLRGS ANRTCQVNGR WSGQTAICDN GAGYCSNPGI PIGTRKVGSQ YRLEDSVTYH CSRGLTLRGS QRRTCQEGGS WSGTEPSCQD SFMYDTPQEV AEAFLSSLTE TIEGVDAEDG HGPGEQQKR

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