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Recombinant human EphA2 protein

CAT: 0112-ATGP3378-050Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3378-050Size:50 µg
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Description
EPHA2, also known as ephrin type-A receptor 2, is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. It is implicated as positional labels that may guide the development of neural topographic maps. It has also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. Recombinant human EPHA2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques
Specifications
Human EphA2 is coated at 2 µg/mL (100 ul/well) can bind Human Ephrin-A1 (CAT# ATGP3782) in a Functional ELISA assay.
Product Name Alternative
EPH receptor A2, Ephrin type-A receptor 2, EPHA2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, ARCC2, CTPA, CTPP1, CTRCT6
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Measured by its binding ability in a functional ELISA with Human Ephrin-A1 (CAT# ATGP3782) .
Molecular Weight
57.3 kDa (520aa)
Additionnal Information
EphA2, Ephrin type-A receptor 2, EPHA2, ARCC2, CTPA, CTPP1, CTRCT6, ECK, AW545284, EC 2.7.10.1, Eck , Eph receptor A2, EPHA2, EPHA2_HUMAN, Ephrin receptor, Ephrin receptor EphA2, Ephrin type A receptor 2, Ephrin type-A receptor 2, Epithelial cell kinase, Epithelial cell receptor protein tyrosine kinase, Myk 2, Myk2, Sek 2Sek2, Tyrosine protein kinase receptor ECK, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, ATGP3378-10 µg, ATGP3378-20 µg, ATGP3378-50 µg, ATGP3378-100 µg, ATGP3378-250 µg, ATGP3378-500 µg, ATGP3378-1 mg, ATGP3378-10, ATGP3378-20, ATGP3378-50, ATGP3378-100, ATGP3378-250, ATGP3378-500, ATGP3378-1
References & Citations
Flanagan JG., et al. (1998) Annu Rev Neurosci. 21:309-345.; ; Cheng N., et al. (2002) Cytokine Growth Factor Rev. 13:75-85.
Other References
Kim SM et al., Developing CAR-T/NK cells that target EphA2 for non-small cell lung cancer treatment. (Front Immunol. 2025) {https://pubmed.ncbi.nlm.nih.gov/40181964/}
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_004422.2
Uniprot Accession Number
P29317
Species
Human
N Terminal Sequence
Ala
AA Sequence
KEVVLLD FAAAGGELGW LTHPYGKGWD LMQNIMNDMP IYMYSVCNVM SGDQDNWLRT NWVYRGEAER IFIELKFTVR DCNSFPGGAS SCKETFNLYY AESDLDYGTN FQKRLFTKID TIAPDEITVS SDFEARHVKL NVEERSVGPL TRKGFYLAFQ DIGACVALLS VRVYYKKCPE LLQGLAHFPE TIAGSDAPSL ATVAGTCVDH AVVPPGGEEP RMHCAVDGEW LVPIGQCLCQ AGYEKVEDAC QACSPGFFKF EASESPCLEC PEHTLPSPEG ATSCECEEGF FRAPQDPASM PCTRPPSAPH YLTAVGMGAK VELRWTPPQD SGGREDIVYS VTCEQCWPES GECGPCEASV RYSEPPHGLT RTSVTVSDLE PHMNYTFTVE ARNGVSGLVT SRSFRTASVS INQTEPPKVR LEGRSTTSLS VSWSIPPPQQ SRVWKYEVTY RKKGDSNSYN VRRTEGFSVT LDDLAPDTTY LVQVQALTQE GQGAGSKVHE FQTLSPEGSG NLAV

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