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Recombinant human LAMTOR4 protein

CAT: 0112-ATGP2791-004Size: 4 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP2791-004Size:4 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LAMTOR4 is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Recombinant human LAMTOR4 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Ragulator complex protein LAMTOR4, C7orf59
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
13.1 kDa (122aa) confirmed by MALDI-TOF
Additionnal Information
LAMTOR4, Ragulator complex protein LAMTOR4, C7orf59, ATGP2791-10 µg, ATGP2791-20 µg, ATGP2791-50 µg, ATGP2791-100 µg, ATGP2791-250 µg, ATGP2791-500 µg, ATGP2791-1 mg, ATGP2791-10, ATGP2791-20, ATGP2791-50, ATGP2791-100, ATGP2791-250, ATGP2791-500, ATGP2791-1
References & Citations
Bar-Peled L., et al. (2011) Cell. 150:1196-1208; ; Burkard T.R., et al. (2012) BMC Syst. Biol. 5:17-17
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001008396
Uniprot Accession Number
Q0VGL1
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMTSALTQ GLERIPDQLG YLVLSEGAVL ASSGDLENDE QAASAISELV STACGFRLHR GMNVPFKRLS VVFGEHTLLV TVSGQRVFVV KRQNRGREPI DV

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