Recombinant human Complement Factor B protein

CAT: 0112-ATGP2479-500Size: 500 µgDry Ice: NoHazardous: No
CAT#:0112-ATGP2479-500Size:500 µg
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Description
CFB encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. Recombinant human CFB-Bb protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Name Alternative
Complement factor B, AHuS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
59.4 kDa (528aa)
Additionnal Information
Complement Factor B, complement factor B, AHuS4, BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2, ATGP2479-10 µg, ATGP2479-20 µg, ATGP2479-50 µg, ATGP2479-100 µg, ATGP2479-250 µg, ATGP2479-500 µg, ATGP2479-1 mg, ATGP2479-10, ATGP2479-20, ATGP2479-50, ATGP2479-100, ATGP2479-250, ATGP2479-500, ATGP2479-1
References & Citations
Wu, L., et al. (2013) Invest. Ophthalmol. Vis. Sci. 54 (1), 170-174; ; Thakkinstian, A., et al. (2012) Am. J. Epidemiol. 176 (5), 361-372;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001701
Uniprot Accession Number
P00751
Species
Human
AA Sequence
KIVLDPS GSMNIYLVLD GSDSIGASNF TGAKKCLVNL IEKVASYGVK PRYGLVTYAT YPKIWVKVSE ADSSNADWVT KQLNEINYED HKLKSGTNTK KALQAVYSMM SWPDDVPPEG WNRTRHVIIL MTDGLHNMGG DPITVIDEIR DLLYIGKDRK NPREDYLDVY VFGVGPLVNQ VNINALASKK DNEQHVFKVK DMENLEDVFY QMIDESQSLS LCGMVWEHRK GTDYHKQPWQ AKISVIRPSK GHESCMGAVV SEYFVLTAAH CFTVDDKEHS IKVSVGGEKR DLEIEVVLFH PNYNINGKKE AGIPEFYDYD VALIKLKNKL KYGQTIRPIC LPCTEGTTRA LRLPPTTTCQ QQKEELLPAQ DIKALFVSEE EKKLTRKEVY IKNGDKKGSC ERDAQYAPGY DKVKDISEVV TPRFLCTGGV SPYADPNTCR GDSGGPLIVH KRSRFIQVGV ISWGVVDVCK NQKRQKQVPA HARDFHINLF QVLPWLKEKL QDEDLGFL

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