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Recombinant human DTD1 protein

CAT: 0112-ATGP1831-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1831-020Size:20 µg
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Description
DTD1 hydrolyzes D-tyrosyl-tRNA (Tyr) into D-tyrosine and free tRNA (Tyr) . It could be a defense mechanism against a harmful effect of D-tyrosine. DTD1 may be a risk factor for aspirin-intolerant asthma (AIA) by catalyzing the hydrolysis of D-tryptophan and interacting with the tyrosyl-tRNA synthetase (tyrRS) enzyme, which promotes a pro-inflammatory phenotype. This protein is localize to the DuE (DNA unwinding element) s of active replication origins. Recombinant human DTD1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
D-tyrosyl-tRNA deacylase 1, bA379J5.3, bA555E18.1, C20orf88, DuEB, HARS2, pqn-68
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
25.9 kDa (232aa) confirmed by MALDI-TOF
Additionnal Information
DTD1, D-tyrosyl-tRNA deacylase 1, bA379J5.3, bA555E18.1, C20orf88, DuEB, HARS2, pqn-68, ATGP1831-10 µg, ATGP1831-20 µg, ATGP1831-50 µg, ATGP1831-100 µg, ATGP1831-250 µg, ATGP1831-500 µg, ATGP1831-1 mg, ATGP1831-10, ATGP1831-20, ATGP1831-50, ATGP1831-100, ATGP1831-250, ATGP1831-500, ATGP1831-1
References & Citations
Pasaje CF, et al. (2011) Int J Mol Med. 28 (1) :129-37. ; ; Chowdhury A, et al. (2010) Mol Cell Biol. 30 (6) :1495-507.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_543010
Uniprot Accession Number
Q8TEA8
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMKAVVQR VTRASVTVGG EQISAIGRGI CVLLGISLED TQKELEHMVR KILNLRVFED ESGKHWSKSV MDKQYEILCV SQFTLQCVLK GNKPDFHLAM PTEQAEGFYN SFLEQLRKTY RPELIKDGKF GAYMQVHIQN DGPVTIELES PAPGTATSDP KQLSKLEKQQ QRKEKTRAKG PSESSKERNT PRKEDRSASS GAEGDVSSER EP

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