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Recombinant human 4E-BP2/EIF4EBP2 protein

CAT: 0112-ATGP0964-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0964-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EIF4EBP2 is a member of the eukaryotic translation initiation factor 4E binding protein family. This protein binds eIF4E and inhibits translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. It mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway. Regulation of this protein has been implicated in cell proliferation, cell differentiation and viral infection. Recombinant human EIF4EBP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Eukaryotic translation initiation factor 4E binding protein 2, 4EBP2, PHASII, eIF4E-binding protein 2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
15.1 kDa (140aa) confirmed by MALDI-TOF
Additionnal Information
EIF4EBP2, Eukaryotic translation initiation factor 4E binding protein 2, 4EBP2, PHASII, ATGP0964-10 µg, ATGP0964-20 µg, ATGP0964-50 µg, ATGP0964-100 µg, ATGP0964-250 µg, ATGP0964-500 µg, ATGP0964-1 mg, ATGP0964-10, ATGP0964-20, ATGP0964-50, ATGP0964-100, ATGP0964-250, ATGP0964-500, ATGP0964-1
References & Citations
Pause A., et al. (1994) Nature. 371650001) :762-7.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl.
Scientific Category
Signal Transduction
NCBI Accession Number
NP_004087.1
Uniprot Accession Number
Q13542
Species
Human
AA Sequence
MSSSAGSGHQ PSQSRAIPTR TVAISDAAQL PHDYCTTPGG TLFSTTPGGT RIIYDRKFLL DRRNSPMAQT PPCHLPNIPG VTSPGTLIED SKVEVNNLNN LNNHDRKHAV GDDAQFEMDI

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