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Recombinant human CLIC1 protein

CAT: 0112-ATGP0568-100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP0568-100Size:100 µg
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Description
CLIC1 (Chloride intracellular channel 1), also referred to as NCC27, is a member of the highly conserved family of chloride ion channels that function in both soluble and integral membrane forms. This protein is a monomeric protein that contains a redox-active site similar to glutaredoxin; it functions as an anion-selective channel. It forms a dimer when oxidized and is then able to form chloride ion channels in bilayers and vesicles, whereas a reducing environment prevents this from occurring. Recombinant human CLIC1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Name Alternative
Chloride intracellular channel protein 1, G6, NCC27, Chloride intracellular channel protein 1 hRNCC, Nuclear chloride ion channel 27, p64CLCP, Chloride channel ABP, Chloride intracellular channel 1, CLIC 1, NCC 27, Nuclear chloride ion channel protein, Regulatory nuclear chloride ion channel protein, RNCC protein.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by BCA assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
29.0 kDa (261aa), confirmed by MALDI-TOF
Additionnal Information
CLIC1, ATGP0568-10 µg, ATGP0568-20 µg, ATGP0568-50 µg, ATGP0568-100 µg, ATGP0568-250 µg, ATGP0568-500 µg, ATGP0568-1 mg, ATGP0568-10, ATGP0568-20, ATGP0568-50, ATGP0568-100, ATGP0568-250, ATGP0568-500, ATGP0568-1
References & Citations
Warton K, et al. (2002) J Biol Chem. 277 (29) :26003-11.; ; Singh H, et al. (2007) FEBS J. 274 (24) :6306-16;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001279.2
Uniprot Accession Number
O00299
Species
Human
AA Sequence
MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K

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