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Human PPME1 antibody

CAT: 0112-ATGA0449-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0449-050Size:50 µL
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Description
PPME1, also known protein phosphatase methylesterase-1 (PME1), catalyzes the demethylation and inactivation of protein phosphatase (PP2A), which is a multimeric phosphoserine/ threonine protein phosphatase associated with growth inhibition and cell cycle arrest. It can demethylate PP2A catalytic subunit in vitro and okadaic acid treatment is capable of inhibiting this reaction. It is conserved from yeast to human and contains a motif found in lipases having a catalytic triad activated serine as their active site nucleophile.
Product Name Alternative
Protein phosphatase methylesterase 1, FLJ22226, PME-1
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human PPME1 (1-386aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT29G3
Conjugation
Unconjugated
Applications
ELISA, WB
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
PPME1, Protein phosphatase methylesterase 1, FLJ22226, PME-1, ATGA0449-10 µg, ATGA0449-20 µg, ATGA0449-50 µg, ATGA0449-100 µg, ATGA0449-250 µg, ATGA0449-500 µg, ATGA0449-1 mg, ATGA0449-10, ATGA0449-20, ATGA0449-50, ATGA0449-100, ATGA0449-250, ATGA0449-500, ATGA0449-1
References & Citations
Ogris E., et al. (1999) J. Biol. Chem. 274: 14382-14391.; ; Gagnon S.N., et al. (2002) Biochem. J. 368: 263-271.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Signal Transduction
NCBI Accession Number
NP_057231
Uniprot Accession Number
Q9Y570
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PPME1 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. ; ; Lane 1.: HeLa cell lysate ; ; Lane 2.: K562 cell lysate ; ; Lane 3.: A549 cell lysate

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