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Human CPOX antibody

CAT: 0112-ATGA0414-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0414-050Size:50 µL
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Description
Coproporphyrinogen-III oxidase, mitochondrial precursor, also known as CPOX, is a 454 amino acid mitochondrial enzyme that is localized to the inner membrane space of erythrocytes. It participates in the sixth step of heme biosynthesis by catalyzing the formation of protoporphyrinogen IX from coproporphyrinogen III. Mutations in human CPOX gene predict the clinical outcome of the disease, with either hepatic hereditary coproporphyria or hematological manifestations of erythropoietic harderoporphyria.
Product Name Alternative
Coproporphyrinogen-III oxidase mitochondrial precursor, Coproporphyrinogen-III oxidase, mitochondrial precursor, CPO, CPX, HCP
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human CPOX (111-454aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
AT36B10
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
CPOX, Coproporphyrinogen-III oxidase mitochondrial precursor, Coproporphyrinogen-III oxidase, mitochondrial precursor, CPO, CPX, HCP, ATGA0414-10 µg, ATGA0414-20 µg, ATGA0414-50 µg, ATGA0414-100 µg, ATGA0414-250 µg, ATGA0414-500 µg, ATGA0414-1 mg, ATGA0414-10, ATGA0414-20, ATGA0414-50, ATGA0414-100, ATGA0414-250, ATGA0414-500, ATGA0414-1
References & Citations
Kim DH., et al. (2013) J Biochem. 154 (6) : 551-9.; ; Barbaro M., et al. (2012) Clin Genet. 81 (3) : 249-56.; ; Rosipal R., et al. (1999) Hum Mutat. 13 (1) : 44-53.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Signal Transduction
NCBI Accession Number
NP_000088
Uniprot Accession Number
P36551
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CPOX antibody (1:500) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. ; ; Lane 1.: Recombinant protein CPOX ; ; Lane 2.: 293T cell lysate ; ; Lane 3.: HepG2 cell lysate ; ; Lane 4.: A549 cell lysate ; ; Lane 5.: Jurkat cell lysate ; ; Lane 6.: K562 cell lysate ; ; Lane 7.: LnCaP cell lysate
IF Description
ICC/IF analysis of CPOX in Hep3B cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human CPOX antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green) .

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