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Human QPRT antibody

CAT: 0112-ATGA0412-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0412-050Size:50 µL
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Description
Quinolinate phosphoribosyltransferase, also known as QPRT, is a major enzyme in the catabolism of quinolinate. It is an intermediate in the tryptophannicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide and pyrophosphate. Elevation of QPRT levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
Product Name Alternative
Nicotinate nucleotide pyrophosphorylase (carboxylating), Nicotinate nucleotide pyrophosphorylase carboxylating, Quinolinate phosphoribosyltransferase, QPRTase, QAPRTase
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human QPRT (1-297aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
AT24C4
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
QPRT, ATGA0412-10 µg, ATGA0412-20 µg, ATGA0412-50 µg, ATGA0412-100 µg, ATGA0412-250 µg, ATGA0412-500 µg, ATGA0412-1 mg, ATGA0412-10, ATGA0412-20, ATGA0412-50, ATGA0412-100, ATGA0412-250, ATGA0412-500, ATGA0412-1
References & Citations
Cao H., et al. (2002) Biochemistry. 41 (10) : 3520-8.; ; Liu H., et al. (2007) J Mol Biol. 373 (3) : 755-63.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Neuroscience
NCBI Accession Number
NP_055113
Uniprot Accession Number
Q15274
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human QPRT antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1 : HepG2 cell lysate; ; Lane 2 : K562 cell lysate
IF Description
ICC/IF analysis of QPRT in Hep3B cells. The cell was stained with ATGA0412 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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