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Human ASNA1 antibody

CAT: 0112-ATGA0293-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0293-050Size:50 µL
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Description
ASNA1, also as known as ARSA and TRC40, is the human homolog of the bacterial arsA, a member of the ATPase superfamily. ArsA and ArsB have been postulated to form a membrane complex which functions as an anion-translocating. It recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ArsA hydrolyses ATP in the presence of its anionic substrate antimonite and produces resistance to arsenite and antimonite. The active form of ArsA is a homodimer with four nucleotide binding sites, two from each monomer.
Product Name Alternative
ATPase ASNA1, ARSA-I, ARSA1, ASNA-I, GET3, hASNA-I, TRC40
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human ASNA1 (1-348aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
AT2A1
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF, FACS
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
ASNA1, ATGA0293-10 µg, ATGA0293-20 µg, ATGA0293-50 µg, ATGA0293-100 µg, ATGA0293-250 µg, ATGA0293-500 µg, ATGA0293-1 mg, ATGA0293-10, ATGA0293-20, ATGA0293-50, ATGA0293-100, ATGA0293-250, ATGA0293-500, ATGA0293-1
References & Citations
Ota T and Suzuki Y. (2004) Nat genet 36 (1) : 40-5.; ; Kurdi-Haidar B.. (1996) Genomics 36 (3) : 486-91.; ; Stefanovic S. (2007) Cell 128 (6) : 1147-59.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot, ICC/IF and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Metabolism
NCBI Accession Number
NP_004308
Uniprot Accession Number
O43681
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human ASNA1 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. ; ; Lane 1.: HeLa cell lysate ; ; Lane 2.: 293T cell lysate ; ; Lane 3.: MCF7 cell lysate
FACS Description
Flow cytometry analysis of ASNA1 in HeLa cell line, staining at 2-5ug for 1x10^6cells (red line) . The secondary antibody used goat anti-mouse IgG Alexa fluor 488 conjugate. Isotype control antibody was mouse IgG (black line) .
IF Description
ICC/IF analysis of ASNA1 in HeLa cells. The cell was stained with ATGA0293 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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