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Human PRPS1 antibody

CAT: 0112-ATGA0586-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0586-100Size:100 µL
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Description
PRPS1 is an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. A mutation in PRPS1 may result in PRPS superactivity, a disease characterized by gout and the overproductionof purine nucleotides, uric acid and PRPP. PRPS1 mutations can also lead to a reduction in PRPS1 activity resulting in ARTS syndrome or CMTX5 (Charcot-Marie-Tooth disease X-linked recessive type 5) .
Product Name Alternative
Ribose-phosphate pyrophosphokinase 1, ARTS, CMTX5, PPRibP, PRSI, DFN2, DFNX1, Ribose-phosphate pyrophosphokinase 1 EC 2.7.6.1, KIAA0967, Phosphoribosyl pyrophosphate synthetase I, PRS I, PRS-I, Ribose phosphate pyrophosphokinase I
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human PRPS1 (1-318aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
AT1E11
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
PRPS1, ATGA0586-10 µg, ATGA0586-20 µg, ATGA0586-50 µg, ATGA0586-100 µg, ATGA0586-250 µg, ATGA0586-500 µg, ATGA0586-1 mg, ATGA0586-10, ATGA0586-20, ATGA0586-50, ATGA0586-100, ATGA0586-250, ATGA0586-500, ATGA0586-1
References & Citations
Ishizuka T, et al. (1992) Biochim Biophsy Acta 241130 (2) : 139-48.; ; Kim HJ, et al. (2007) Arn J Hum Gernet 81 (3) :552-8.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Cancer
NCBI Accession Number
NP_002755
Uniprot Accession Number
P60891
WB Description
The cell lysate (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human PRPS1 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: 293T cell lysate
IF Description
ICC/IF analysis of PRPS1 in HeLa cells. The cell was stained with ATGA0586 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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