Human Snail antibody

CAT: 0112-ATGA0288-050Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0112-ATGA0288-050Size:50 µL

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Description

SNAI1, also known as Snail homolog 1, is involved in the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. This protein binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription. Both SNAI1 and SLUG belong to the snail C2H2-type zinc-finger protein family. SLUG is a transcriptional repressor, involved in the generation and migration of neural crest cells. SNAI1 is expressed in mesenchymal, epithelial cell lines and highest expression in kidney.

Product Name Alternative

Snail homolog 1, dJ710H13.1, SLuGH2, SNA, SNAH, SNAIL, SNAIL1

Host

Mouse

Antigen Species

Human

Reactivity

Human

Immunogen

Recombinant human SNAI1 (1-264aa) purified from E. coli

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

AT2D5

Conjugation

Unconjugated

Applications

ELISA, WB

Purification Method

By protein-A affinity chromatography

Concentration

1 mg/mL (determined by BCA assay)

Additionnal Information

Snail, SNAI1, ATGA0288-10 µg, ATGA0288-20 µg, ATGA0288-50 µg, ATGA0288-100 µg, ATGA0288-250 µg, ATGA0288-500 µg, ATGA0288-1 mg, ATGA0288-10, ATGA0288-20, ATGA0288-50, ATGA0288-100, ATGA0288-250, ATGA0288-500, ATGA0288-1

References & Citations

Batlle. E., et al. (2000) Nat Cell Biol 2: 84-89.; ; Yook. J.I., et al. (2005) J Biol Chem 280: 11740-11748.; ; Twigg. S.R. and Wilkie. A.O.M. (1999) Hum Genet 105: 320-326.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol

Applications Notes

The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_005976

Uniprot Accession Number

O95863

WB Description

The cell lysate of A549 (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human SNAI1 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

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