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Human CDK4 antibody

CAT: 0112-ATGA0272-100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0272-100Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclin-dependent kinase 4, also known as CDK4, belongs to the cyclin-dependent kinases (CDK) family. CDKs are a family of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDK4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin up-regulates CDK4 activity, whereas binding to the CDK inhibitor p16 down-regulates CDK4 activity.
Product Name Alternative
Cyclin-dependent kinase 4, CMM3, PSK-J3
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human CDK4 (1-303aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
AT6D10
Conjugation
Unconjugated
Applications
ELISA, WB
Purification Method
By protein-A affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
CDK4, ATGA0272-10 µg, ATGA0272-20 µg, ATGA0272-50 µg, ATGA0272-100 µg, ATGA0272-250 µg, ATGA0272-500 µg, ATGA0272-1 mg, ATGA0272-10, ATGA0272-20, ATGA0272-50, ATGA0272-100, ATGA0272-250, ATGA0272-500, ATGA0272-1
References & Citations
Coleman KG, et al. (1997) . J. Biol. Chem. 272 (30) : 18869-74.; ; Li J, Melvin WS, Tsai MD, Muscarella P (2004) . Biochemistry 43 (14) : 4394-9.; ; Dai K, Kobayashi R, Beach D (1996) . J. Biol. Chem. 271 (36) : 22030-4.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Cell Cycle
NCBI Accession Number
NP_000066
Uniprot Accession Number
P11802
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CDK4 antibody (1:500) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1.: HeLa cell lysate;

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