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Recombinant human CDK4 protein

CAT: 0112-ATGP1724-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP1724-500Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclin-dependent kinase 4, also known as CDK4, belongs to the Cyclin-dependent kinases (CDK) family. CDK are the catalytic subunits of the cyclin/cdk complexes, which phosphorylate substrates on threonine/serine residues. CDK4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin upregulates CDK4 activity, whereas binding to the CDK inhibitor p16 downregulates CDK4 activity. Recombinant human CDK4 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Name Alternative
Cyclin-dependent kinase 4, CMM3, PSK-J3
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
36.1 kDa (326aa)
Additionnal Information
CDK4, Cyclin-dependent kinase 4, CMM3, PSK-J3, ATGP1724-10 µg, ATGP1724-20 µg, ATGP1724-50 µg, ATGP1724-100 µg, ATGP1724-250 µg, ATGP1724-500 µg, ATGP1724-1 mg, ATGP1724-10, ATGP1724-20, ATGP1724-50, ATGP1724-100, ATGP1724-250, ATGP1724-500, ATGP1724-1
References & Citations
Serrano M., et al. (1993) Nature.366:704-707.; ; Kato J Y., et al. (1994) Mol Cell Biol. 14:2713-2721.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Cell Cycle
NCBI Accession Number
NP_000066
Uniprot Accession Number
P11802
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMATSRYE PVAEIGVGAY GTVYKARDPH SGHFVALKSV RVPNGGGGGG GLPISTVREV ALLRRLEAFE HPNVVRLMDV CATSRTDREI KVTLVFEHVD QDLRTYLDKA PPPGLPAETI KDLMRQFLRG LDFLHANCIV HRDLKPENIL VTSGGTVKLA DFGLARIYSY QMALTPVVVT LWYRAPEVLL QSTYATPVDM WSVGCIFAEM FRRKPLFCGN SEADQLGKIF DLIGLPPEDD WPRDVSLPRG AFPPRGPRPV QSVVPEMEES GAQLLLEMLT FNPHKRISAF RALQHSYLHK DEGNPE

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