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Human CMBL antibody

CAT: 0112-ATGA0233-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0233-050Size:50 µL
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Description
CMBL (carboxymethylenebutenolidase homolog) is a 245 amino acid cytosolic protein and cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL is the human homolog of Pseudomonas dienelactone hydrolase, a protein that participates in the bacterial halocatechol degradation pathway. That is ubiquitously expressed with high expression in liver, colon, kidney and small intestine, where it acts as a bioactivating enzyme for a prodrug type angiotensin II type 1 receptor antagonist known as olmesartan medoxomil. CMBL is inhibited by p-chloromercuribenzoate (PCMB) .
Product Name Alternative
Carboxymethylenebutenolidase homolog
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human CMBL (1-245aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
AT2B11
Conjugation
Unconjugated
Applications
ELISA, WB
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
CMBL, ATGA0233-10 µg, ATGA0233-20 µg, ATGA0233-50 µg, ATGA0233-100 µg, ATGA0233-250 µg, ATGA0233-500 µg, ATGA0233-1 mg, ATGA0233-10, ATGA0233-20, ATGA0233-50, ATGA0233-100, ATGA0233-250, ATGA0233-500, ATGA0233-1
References & Citations
Ishizuka T, et al. (Apr 2010) . J Biol Chem. 16285 (16) :11892-902. ; ; Yang X, et al. (Mar 2010) . J Proteome Res. 59 (3) :1402-15.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Metabolism
NCBI Accession Number
NP_620164
Uniprot Accession Number
Q96DG6
WB Description
The cell lysates of HeLa (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CMBL antibody (1:500 ~ 1:5000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

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