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Human BAK antibody

CAT: 0112-ATGA0183-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATGA0183-050Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAK1 encodes an receptor-like kinase (RLK) with a putative extracellular domain, a single transmembrane domain, an intracellular-juxtamembrane domain, and a kinase domain. BAK1 expression is associated with the progression of Prostate cancer (CaP) . BAK1 appears to function in distinct receptor-signaling complexes to integrate multiple microbe-associated molecular pattern (MAMP) perception into downstream-signaling events. BAK1 can serve multiple purposes to simultaneously modulate MAMP-receptor complexes, BR signaling, and cell death for the benefit of bacterial infection, life style, and fitness.
Product Name Alternative
BCL2-antagonist/killer 1, Apoptosis regulator BAK, BAK, BAK-LIKE, Bcl-2 homologous antagonist/killer, Bcl2-L-7, BAK-1, BAK 1, BAK like, Bak NT, BAK1, Bcl 2 homologous antagonist/killer, Bcl 2 like 7 protein, Bcl2 homologous antagonist killer, Bcl2 like 7 Protein, BCL2-antagonist/killer 1, BCL2L7, CDN 1, CDN1, Cell death inhibitor 1, MGC117255, MGC3887, NBak, Pro apoptotic protein BAK
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human BAK1 (29-187aa) purified from E.coli
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
AT38E2
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF, FACS
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
BAK, ATGA0183-10 µg, ATGA0183-20 µg, ATGA0183-50 µg, ATGA0183-100 µg, ATGA0183-250 µg, ATGA0183-500 µg, ATGA0183-1 mg, ATGA0183-10, ATGA0183-20, ATGA0183-50, ATGA0183-100, ATGA0183-250, ATGA0183-500, ATGA0183-1
References & Citations
Birgit Kemmerling, et al. (2008) Plant Signal Behav, 3 (2) : 116-118.; ; Libo Shan, et al. (2008) Cell Host Microbe, 4 (1) : 17-27.; ; Xu-Bao Shi, et al. (2007) Proc Natl Acad Sci U S A, 104 (50) : 19983-19988.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot, ICC/IF and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Apoptosis
NCBI Accession Number
NP_001179
Uniprot Accession Number
Q16611
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BAK1 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1 : 293T cell lysate; ; Lane 2 : HeLa cell lysate; ; Lane 3 : A431 cell lysate; ; Lane 4 : A549 cell lysate; ; Lane 5 : Jurkat cell lysate; ; Lane 6 : MCF7 cell lysate; ; Lane 7 : PC3 cell lysate
FACS Description
Flow cytometry analysis of BAK1 in HeLa cell line, staining at 2-5ug for 1x10^6cells (red line) . The secondary antibody used goat anti-mouse IgG Alexa fluor 488 conjugate. Isotype control antibody was mouse IgG (black line) .
IF Description
ICC/IF analysis of BAK1 in HeLa cells. The cell was stained with ATGA0183 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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