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Human BMP-7 antibody

CAT: 0112-ABM0615-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ABM0615-050Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMP-7 (bone morphogenetic protein-7), also known as OP-1 (osteogenic protein-1), is a member of the transforming growth factorbeta (TGFbeta) superfamily. BMP-7 plays an essential role during ontogeny of the mammalian eye and kidney, also, is expressed in heart, lung, small intestine, limb bud and teeth. In addition, noggin, one of the soluble BMP antagonists, regulated the action of BMPs on mesenchymal precursor cells, partially through a feedback type of inhibition.
Product Name Alternative
BMP 7, Bone morphogenetic protein 7, Eptotermin alfa, OP-1, Osteogenic protein 1
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human BMP7 (293-431aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG1 κ
Clone
40000000
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
Osteogenic protein1, Osteogenic protein 1, OP-1, OP1, OP 1, Eptotermin alfa, Bone morphogenetic protein 7, BMP 7, BMP7, BMP-7, ABM0615-10 µg, ABM0615-20 µg, ABM0615-50 µg, ABM0615-100 µg, ABM0615-250 µg, ABM0615-500 µg, ABM0615-1 mg, ABM0615-010, ABM0615-020, ABM0615-050, ABM0615-100, ABM0615-250, ABM0615-500, ABM0615-01M
References & Citations
Gregory KE., et al. (2005) J. Biol, Chem. 280, 27970-27980.; ; Sampath Tk., et al. (1990) J. Biol. Chem. 265:13198-13205.; ; Godin RE., et al. (1998) Development. 125:3473-3482.; ; Groppe J., et al. (2002) Nature. 420:636-642.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_001710
Uniprot Accession Number
P18075
WB Description
The extracts of mouse kidney (MK) and rat heart (RH) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP7 antibody (1:1,000) . Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
IF Description
ICC/IF analysis of BMP7 in HeLa cells. The cell was stained with ABM0615 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .

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