Apocynin-d3

• Description :

  Apocynin-d3 is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].

• CAS Number :

  [80404-23-5]

• Product Name Alternative :

  Acetovanillone-d3

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Apoptosis; Autophagy

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Apoptosis; Autophagy

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  99.85

• Solubility :

  10 mM in DMSO

• Smiles :

  [2H]C([2H])([2H])OC1=CC(C(C)=O)=CC=C1O

• Molecular Formula :

  C9H7D3O3

• Molecular Weight :

  169.19

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Stolk J, et al. Am J Respir Cell Mol Biol, 1994, 11 (1), 95-102.|[3]Stefanska J, et al. Mediators Inflamm, 2008, 106507.|[4]Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 181 (5) :636-48.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported