Apocynin-d3

• Description:

  Apocynin-d3 is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].

• Product Name Alternative:

  Acetovanillone-d3

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Apoptosis; Autophagy

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  99.85

• Solubility:

  10 mM in DMSO

• Smiles:

  [2H]C([2H])([2H])OC1=CC(C(C)=O)=CC=C1O

• Molecular Formula:

  C9H7D3O3

• Molecular Weight:

  169.19

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Stolk J, et al. Am J Respir Cell Mol Biol, 1994, 11 (1), 95-102.|[3]Stefanska J, et al. Mediators Inflamm, 2008, 106507.|[4]Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 181 (5) :636-48.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [80404-23-5]