Apocynin

• Description :

  Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474) -induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].

• CAS Number :

  [498-02-2]

• Product Name Alternative :

  Acetovanillone

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  NADPH Oxidase

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Apocynin.html

• Purity :

  99.99

• Solubility :

  DMSO : ≥ 100 mg/mL|H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC(C1=CC=C(O)C(OC)=C1)=O

• Molecular Formula :

  C9H10O3

• Molecular Weight :

  166.18

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Stolk J, et al. Am J Respir Cell Mol Biol, 1994, 11 (1), 95-102.|[2]Stefanska J, et al. Mediators Inflamm, 2008, 106507.|[3]Sun J, et.al. Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass. Sci Rep. 2015 Dec 21;5:18572. |[4]Yamasaki M, et.al. Selective inhibition by apocynin of the proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. Biosci Biotechnol Biochem. 2012;76 (6) :1177-81. |[5]Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 1;81 (5) :636-48.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 1