Apocynin

CAT: 0804-HY-N0088-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0088-01Size:500 mg
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Description
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474) -induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].
CAS Number
[498-02-2]
Product Name Alternative
Acetovanillone
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
NADPH Oxidase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Apocynin.html
Purity
99.99
Solubility
DMSO : ≥ 100 mg/mL|H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C1=CC=C(O)C(OC)=C1)=O
Molecular Formula
C9H10O3
Molecular Weight
166.18
Precautions
H315, H319, H335
References & Citations
[1]Stolk J, et al. Am J Respir Cell Mol Biol, 1994, 11 (1), 95-102.|[2]Stefanska J, et al. Mediators Inflamm, 2008, 106507.|[3]Sun J, et.al. Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass. Sci Rep. 2015 Dec 21;5:18572. |[4]Yamasaki M, et.al. Selective inhibition by apocynin of the proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. Biosci Biotechnol Biochem. 2012;76 (6) :1177-81. |[5]Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 1;81 (5) :636-48.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 1

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