Apocynin

• Description:

  Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474) -induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5].

• Product Name Alternative:

  Acetovanillone

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  NADPH Oxidase

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Apocynin.html

• Purity:

  99.99

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CC(C1=CC=C(O)C(OC)=C1)=O

• Molecular Formula:

  C9H10O3

• Molecular Weight:

  166.18

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Stolk J, et al. Am J Respir Cell Mol Biol, 1994, 11 (1), 95-102.|[2]Stefanska J, et al. Mediators Inflamm, 2008, 106507.|[3]Sun J, et.al. Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass. Sci Rep. 2015 Dec 21;5:18572. |[4]Yamasaki M, et.al. Selective inhibition by apocynin of the proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells. Biosci Biotechnol Biochem. 2012;76 (6) :1177-81. |[5]Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 1;81 (5) :636-48.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 1

• CAS Number:

  [498-02-2]