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P35 Antibody

CAT: 1071-OM635586-01Size: 100 µLDry Ice: NoHazardous: No
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CAT#:1071-OM635586-01Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) ; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Immunogen
The antiserum was produced against synthesized peptide derived from human CDK5R1. AA range:11-60
Antibody Type
Primary Antibodies
Product Name Synonym
CDK5R1 antibody; CDK5R antibody; NCK5A antibody; Cyclin-dependent kinase 5 activator 1 antibody; CDK5 activator 1 antibody; Cyclin-dependent kinase 5 regulatory subunit 1 antibody; TPKII regulatory subunit antibody