Pomalidomide-PEG1-NH2 (hydrochloride)

Pomalidomide-PEG1-NH2 (hydrochloride)

• CAS Number: 2380273-67-4
• UNSPSC Description: Pomalidomide-PEG1-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate, consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/pomalidomide-peg1-nh2-1-hydrochloride.html
• Smiles: [H]Cl.NCCOCC(NC1=CC=CC(C2=O)=C1C(N2C(C3=O)CCC(N3)=O)=O)=O
• Molecular Weight: 410.81
• References & Citations: [1]Lee B, et al. Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug. J Enzyme Inhib Med Chem. 2023 Dec;38(1):51-66.
• Shipping Conditions: Blue Ice