Mecbotamab vedotin

• Description :

  Mecbotamab vedotin (BA3011) is a pH dependent antibody drug conjugate (ADC) targeting AXL. Mecbotamab vedotin can significantly inhibit AXL in DU145 cells and LCLC-103H cells and kills cells. Mecbotamab vedotin can be used for research on cancer such as lung cancer, pancreatic cancer and prostate cancer. The antibody component is Mecbotamab (HY-P9988), and the ADC toxin molecule is Vedotin (HY-15162) [1].

• Product Name Alternative :

  BA3011; CAB-Axl-ADC; CAB-anti-Axl-ADC

• UNSPSC :

  12352100

• Target :

  Antibody-Drug Conjugates (ADCs) ; TAM Receptor

• Type :

  Reference compound

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mecbotamab-vedotin.html

• Purity :

  99.11

• Solubility :

  10 mM in DMSO

• Smiles :

  [Mecbotamabvedotin]

• References & Citations :

  [1]Chang HW, et al. Preclinical development of mecbotamab vedotin (BA3011), a novel, AXL-specific conditional active biologic antibody-drug conjugate. Antib Ther. 2025 Apr 10;8 (2) :145-156.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C, protect from light

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [2460400-64-8]