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1-Naphthohydroxamic acid

CAT: 0957-E6577-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E6577-02Size:25 mg
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Description
1-Naphthohydroxamic acid (Compound 2) demonstrates potent and selective inhibition of HDAC8 (IC50 = 14 μM), exhibiting significantly greater selectivity for HDAC8 compared to class I HDAC1 and class II HDAC6 (IC50 >100 μM) . This compound does not elevate global histone H4 acetylation levels nor decrease total intracellular HDAC activity. Additionally, 1-naphthohydroxamic acid has been shown to promote tubulin acetylation.
CAS Number
6953-61-3
Target
HDAC
Activity
DNA Damage/DNA Repair
Molecular Formula
C11H9NO2

Chemical Information

1-Naphthohydroxamic Acid
CAS Number6953-61-3
PubChem CID23382
IUPAC NameN-hydroxynaphthalene-1-carboxamide
Molecular FormulaC11H9NO2
Molecular Weight187.19
XLogP2.4
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count14
Formal Charge0
Complexity217
SMILES
C1=CC=C2C(=C1)C=CC=C2C(=O)NO
InChI
InChI=1S/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)
InChIKey
JRZGPWOEHDOVMC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Naphthohydroxamic Acid
CAS: 6953-61-3
CID: 23382
Formula: C11H9NO2
MW: 187.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight187.19
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass187.063328530
Monoisotopic Mass187.063328530
Topological Polar Surface Area49.3 Ų
Heavy Atom Count14
Formal Charge0
Complexity217
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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