1-Naphthohydroxamic acid

• Target :

  HDAC

• Related Pathways :

  DNA Damage/DNA Repair|||Chromatin/Epigenetic

• Purity :

  >99.99%

• Bioactivity :

  1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 ?M, demonstrating greater selectivity for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 ?M) . It does not increase global histone H4 acetylation or reduce total intracellular HDAC activity but can induce tubulin acetylation[1][2].

• Smiles :

  ONC(=O)c1cccc2ccccc12

• Molecular Formula :

  C11H9NO2

• Molecular Weight :

  187.19

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  6953-61-3