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XYD049

CAT: 0957-E5854-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E5854-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XYD049 (compound 7d) is a CRBN-based molecular glue targeting GSPT1 (DC50=19 nM), applicable for studying MYC-driven castration-resistant prostate cancer (CRPC) . It demonstrates potent growth inhibition of 22Rv1 cells (IC50=7 nM) and exhibits in vivo antitumor activity. XYD049 downregulates CRPC-associated oncogenes (AR, AR-v7, PSA, c-Myc) in 22Rv1 cells. Structurally, it consists of: 1) a molecular glue linker (NH2-C5-NH-Boc), 2) a CRBN-recruiting E3 ligase ligand (Thalidomide 4-fluoride), and 3) a GSPT1-targeting moiety (GSPT1 ligand-1) . The E3 ligase ligand-linker combination forms conjugate 158.
CAS Number
3006788-11-7
Molecular Formula
C35H35BrN6O10S

Alternative Products

CatalogName
HY-170820-01XYD049

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