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XYD049

CAT: 0931-T205022-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205022-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3006788-11-7
Target
Molecular Glues
Related Pathways
PROTAC
Bioactivity
XYD049 (compound 7d) is a CRBN-type molecular glue targeting GSPT1, with a DC50 of 19 nM, used for researching MYC-driven castration-resistant prostate cancer (CRPC) . It effectively inhibits the growth of 22Rv1 cells (IC50 = 7 nM) and exhibits antitumor efficacy in vivo. XYD049 downregulates CRPC-associated oncogenes in 22Rv1 cells, including AR, AR-v7, PSA, and c-Myc. XYD049 comprises a molecular glue linker (black part) NH2-C5-NH-Boc, a CRBN-type E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a target protein ligand (red part) GSPT1 ligand-1, with the E3 ligase ligand + linker forming the conjugate E3 Ligase Ligand-linker Conjugate 158.
Smiles
O=C(NCCCCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)COC4=CC=5ON=C(C5C=C4NS(=O)(=O)C6=CC(Br)=CC=C6OC)C
Molecular Formula
C35H35BrN6O10S
Molecular Weight
811.656
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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