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REM127

CAT: 0957-E5930-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E5930-01Size:5 mg
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Description
REM127 is a small molecule that restores calcium homeostasis by stabilizing the septin cytoskeleton, thereby preventing pathological calcium influx in models of tauopathies. It improves synaptic plasticity, reduces tau and Aβ pathology, and rescues memory function in disease models. It exhibits a potential for treating Alzheimer’s disease and frontotemporal dementia.
CAS Number
1417823-67-6
Target
Calcium Channel
Activity
Neuronal Signaling
Molecular Formula
C20H20Cl2N4S

Chemical Information

3-(4-Chlorophenyl)-5-[4-[2-(2-chlorophenyl)ethyl]piperazin-1-yl]-1,2,4-thiadiazole
CAS Number1417823-67-6
PubChem CID71186343
IUPAC Name3-(4-chlorophenyl)-5-[4-[2-(2-chlorophenyl)ethyl]piperazin-1-yl]-1,2,4-thiadiazole
Molecular FormulaC20H20Cl2N4S
Molecular Weight419.4
XLogP5.9
Topological Polar Surface Area60.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity455
SMILES
C1CN(CCN1CCC2=CC=CC=C2Cl)C3=NC(=NS3)C4=CC=C(C=C4)Cl
InChI
InChI=1S/C20H20Cl2N4S/c21-17-7-5-16(6-8-17)19-23-20(27-24-19)26-13-11-25(12-14-26)10-9-15-3-1-2-4-18(15)22/h1-8H,9-14H2
InChIKey
YWJORACHBFMAHI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-Chlorophenyl)-5-[4-[2-(2-chlorophenyl)ethyl]piperazin-1-yl]-1,2,4-thiadiazole
CAS: 1417823-67-6
CID: 71186343
Formula: C20H20Cl2N4S
MW: 419.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight419.4
XLogP35.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass418.0785732
Monoisotopic Mass418.0785732
Topological Polar Surface Area60.5 Ų
Heavy Atom Count27
Formal Charge0
Complexity455
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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