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REM127

CAT: 0931-T88556-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T88556-02Size:50 mg
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CAS Number
1417823-67-6
Target
Calcium Channel, Beta Amyloid, Others
Related Pathways
Neuroscience, Metabolism, Membrane transporter/Ion channel, Others
Bioactivity
REM127 is a small molecular compound that modulates cellular calcium homeostasis and provides neuroprotection. It efficiently restores the imbalance of calcium homeostasis in cell models caused by the pathological accumulation of tau protein. Furthermore, REM127 can effectively cross the blood-brain barrier and offers therapeutic benefits in animal models of Alzheimer's disease, particularly in ameliorating synaptic and cognitive deficits and slowing the progression of amyloid-beta and tau pathologies. This compound is utilized in the research of neurodegenerative diseases.
Smiles
ClC=1C=CC(=CC1)C2=NSC(=N2)N3CCN(CCC=4C=CC=CC4Cl)CC3
Molecular Formula
C20H20Cl2N4S
Molecular Weight
419.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

3-(4-Chlorophenyl)-5-[4-[2-(2-chlorophenyl)ethyl]piperazin-1-yl]-1,2,4-thiadiazole
CAS Number1417823-67-6
PubChem CID71186343
IUPAC Name3-(4-chlorophenyl)-5-[4-[2-(2-chlorophenyl)ethyl]piperazin-1-yl]-1,2,4-thiadiazole
Molecular FormulaC20H20Cl2N4S
Molecular Weight419.4
XLogP5.9
Topological Polar Surface Area60.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity455
SMILES
C1CN(CCN1CCC2=CC=CC=C2Cl)C3=NC(=NS3)C4=CC=C(C=C4)Cl
InChI
InChI=1S/C20H20Cl2N4S/c21-17-7-5-16(6-8-17)19-23-20(27-24-19)26-13-11-25(12-14-26)10-9-15-3-1-2-4-18(15)22/h1-8H,9-14H2
InChIKey
YWJORACHBFMAHI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-Chlorophenyl)-5-[4-[2-(2-chlorophenyl)ethyl]piperazin-1-yl]-1,2,4-thiadiazole
CAS: 1417823-67-6
CID: 71186343
Formula: C20H20Cl2N4S
MW: 419.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight419.4
XLogP35.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass418.0785732
Monoisotopic Mass418.0785732
Topological Polar Surface Area60.5 Ų
Heavy Atom Count27
Formal Charge0
Complexity455
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
E5930-01REM127

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