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GRB 14 Polyclonal Antibody

CAT: 0498-bs-13641RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-13641RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Synonyms
Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14
Gene ID
2888
Swiss Prot
Q14449
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
221-320/540
Target
GRB 14
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human GRB 14
Applications
ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Specificity
This antibody may also detect the similar protein GRB10 due to an 83% sequence similarity in the immunogen sequence.
Gene ID URL
2888
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Sheep, Horse, Chicken, Rabbit

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