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HLM006474

CAT: 0957-S8963-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-S8963-02Size:25 mg
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Description
HLM006474 is a small molecule pan-E2F inhibitor that inhibits DNA binding to E2F4 with IC50 of 29.8 μM in A375 cells. HLM006474 induces a reduction in cell proliferation and an increase in apoptosis. The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and HLM006474 is shown to have efficacy in lung cancer.
CAS Number
353519-63-8
Target
CDK
Activity
Cell Cycle
Molecular Formula
C25H25N3O2
Storage Conditions
3 years -20°C powder

Chemical Information

7-[(4-Ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol
CAS Number353519-63-8
PubChem CID2895500
IUPAC Name7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol
Molecular FormulaC25H25N3O2
Molecular Weight399.5
XLogP5.4
Topological Polar Surface Area67.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count30
Formal Charge0
Complexity533
SMILES
CCOC1=C(C=C(C=C1)C(C2=C(C3=C(C=CC(=N3)C)C=C2)O)NC4=CC=CC=N4)C
InChI
InChI=1S/C25H25N3O2/c1-4-30-21-13-11-19(15-16(21)2)23(28-22-7-5-6-14-26-22)20-12-10-18-9-8-17(3)27-24(18)25(20)29/h5-15,23,29H,4H2,1-3H3,(H,26,28)
InChIKey
CYNZBLNMIJNBSF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-[(4-Ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol
CAS: 353519-63-8
CID: 2895500
Formula: C25H25N3O2
MW: 399.5
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight399.5
XLogP35.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass399.19467705
Monoisotopic Mass399.19467705
Topological Polar Surface Area67.3 Ų
Heavy Atom Count30
Formal Charge0
Complexity533
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5754963HLM006474
A20921-500HLM006474 500mg
A20921-100HLM006474 100mg
A20921-5HLM006474 5mg
A20921-50HLM006474 50mg
A20921-25HLM006474 25mg
A20921-10HLM006474 10mg
A20921-2HLM006474 2mg
DPA51963-01E2F Inhibitor, HLM006474

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