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HLM006474

CAT: 0957-S8963-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S8963-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HLM006474 is a small molecule pan-E2F inhibitor that inhibits DNA binding to E2F4 with IC50 of 29.8 μM in A375 cells. HLM006474 induces a reduction in cell proliferation and an increase in apoptosis. The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and HLM006474 is shown to have efficacy in lung cancer.
CAS Number
353519-63-8
Target
CDK
Activity
Cell Cycle
Molecular Formula
C25H25N3O2
Storage Conditions
3 years -20°C powder