GDF7 Polyclonal Antibody

• Background:

  Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2) . Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1) . GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3) . Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4) . GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5) . GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6) . GDF-6 and GDF-7 are closely related to GDF-5 (6) . GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1) .

• Synonyms:

  Bmp12; bone morphogenetic protein 12; GDF-7; Gdf 7; GDF7_HUMAN; growth dferentiation factor 7; Growth/dferentiation factor 7.

• Cellular Locus:

  Secreted

• Host:

  Rabbit

• Immunogen:

  362-410/450

• Target:

  GDF7

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human GDF7

• Applications:

  WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

• Predicted Cross Reactivity:

  Human, Mouse, Rat, Cow, Pig, Horse, Chicken