GDF6 Polyclonal Antibody

CAT: 0498-bs-11843RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-11843RSize:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2) . Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1) . GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3) . Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4) . GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5) . GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6) . GDF-6 and GDF-7 are closely related to GDF-5 (6) . GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1) .
Synonyms
Bmp 13; bmp13; bmp-13; Cartilage Derived Morphogenetic Protein 2; cdmp 2; CDMP2; gdf 6; GDF16 ; Growth dferentiation factor 6; Growth/dferentiation factor 6; GDF6_HUMAN.
Cellular Locus
Secreted
Host
Rabbit
Cross Reactivity
Human
Immunogen
336-410/455
Target
GDF6
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human GDF6
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Predicted Cross Reactivity
Mouse, Rat, Dog, Cow, Horse, Rabbit

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