Products for Research Use Only
RegisterLogin

AZD1080

CAT: 0957-S7145-02Size: 25 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0957-S7145-02Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.
CAS Number
612487-72-6
Target
GSK-3
Activity
PI3K/Akt/mTOR
Molecular Formula
C19H18N4O2
Storage Conditions
2 years -80 in solvent

Chemical Information

Azd-1080

AZD1080 is a member of the class of hydroxyindoles that is 1H-indole substituted by hydroxy, 5-(morpholin-4-ylmethyl)pyridin-2-yl, and cyano groups at positions 2, 3 and 5, respectively. It is a potent, brain permeable inhibitor of human GSK3alpha and GSK3beta with Ki of 6.9 nM and 31 nM, respectively. The drug was being developed by AstraZeneca for the treatment of Alzheimer's disease (clinical trial now discontinued). It has a role as a tau aggregation inhibitor, an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a nitrile, a member of pyridines, a member of morpholines, a tertiary amino compound and a member of hydroxyindoles.

CAS Number612487-72-6
PubChem CID135564570
IUPAC Name2-hydroxy-3-[5-(morpholin-4-ylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile
Molecular FormulaC19H18N4O2
Molecular Weight334.4
XLogP1.8
Topological Polar Surface Area85.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity501
SMILES
C1COCCN1CC2=CN=C(C=C2)C3=C(NC4=C3C=C(C=C4)C#N)O
InChI
InChI=1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2
InChIKey
BLTVBQXJFVRPFK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azd-1080
CAS: 612487-72-6
CID: 135564570
Formula: C19H18N4O2
MW: 334.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight334.4
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass334.14297583
Monoisotopic Mass334.14297583
Topological Polar Surface Area85.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity501
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
S2162-50mgAZD1480
S2162-10mM/1mLAZD1480
S2162-5mgAZD1480
S2162-200mgAZD1480
S2162-1gAZD1480
S2162-10mgAZD1480
S2162-01AZD1480
E4629-1gAZD0780
E0101-5mgAZD6280
S7104-50mgAZD1208

Alternative Products

CatalogName
MBS132584-01AZD1080
A12819-50AZD1080 50mg
A12819-2AZD1080 2mg
A12819-5AZD1080 5mg
A12819-1AZD1080 1mg
A12819-100AZD1080 100mg
A12819-25AZD1080 25mg

Popular Products