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AZD1480

CAT: 0957-S2162-1gSize: 1 gDry Ice: YesHazardous: No
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CAT#:0957-S2162-1gSize:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
935666-88-9
Target
JAK
Applications
Angiogenesis
Smiles
CC1=CC (=NN1) NC2=NC (=NC=C2Cl) NC (C) C3=NC=C (C=N3) F
Molecular Formula
C14H14ClFN8
Additionnal Information
AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
Storage Conditions
2 years -80 in solvent

Chemical Information

Azd-1480

AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential Thrombocythaemia Myelofibrosis.

CAS Number935666-88-9
PubChem CID16659841
IUPAC Name5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Molecular FormulaC14H14ClFN8
Molecular Weight348.76
XLogP2.4
Topological Polar Surface Area104
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity397
SMILES
CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F
InChI
InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
InChIKey
PDOQBOJDRPLBQU-QMMMGPOBSA-N
Chemical Structure
2D Structure
2D structure of Azd-1480
CAS: 935666-88-9
CID: 16659841
Formula: C14H14ClFN8
MW: 348.76
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight348.76
XLogP32.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass348.1013983
Monoisotopic Mass348.1013983
Topological Polar Surface Area104 Ų
Heavy Atom Count24
Formal Charge0
Complexity397
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
2315-5AZD1480
A10110-25AZD1480 25mg
A10110-50AZD1480 50mg
A10110-10AZD1480 10mg
A10110-200AZD1480 200mg
A10110-100AZD1480 100mg
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A10110-10mM-DAZD1480 10mM * 1mL in DMSO
441975-01AZD1480 discontinued. See 169614

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