AZD1480

CAT: 0957-S2162-5mgSize: 5 mgDry Ice: YesHazardous: No

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CAT#:0957-S2162-5mgSize:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

935666-88-9

Target

JAK

Applications

Angiogenesis

Smiles

CC1=CC (=NN1) NC2=NC (=NC=C2Cl) NC (C) C3=NC=C (C=N3) F

Molecular Formula

C14H14ClFN8

Additionnal Information

AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.

Storage Conditions

2 years -80 in solvent

Chemical Information

Azd-1480

AZD1480 has been used in trials studying the treatment of Solid Malignancies, Post-Polycythaemia Vera, Primary Myelofibrosis (PMF), and Essential Thrombocythaemia Myelofibrosis.

CAS Number	935666-88-9
PubChem CID	16659841
IUPAC Name	5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Molecular Formula	C14H14ClFN8
Molecular Weight	348.76
XLogP	2.4
Topological Polar Surface Area	104
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Heavy Atom Count	24
Formal Charge	0
Complexity	397

SMILES

CC1=CC(=NN1)NC2=NC(=NC=C2Cl)N[C@@H](C)C3=NC=C(C=N3)F

InChI

InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1

InChIKey

PDOQBOJDRPLBQU-QMMMGPOBSA-N

Chemical Structure

2D Structure

CAS: 935666-88-9

CID: 16659841

Formula: C14H14ClFN8

MW: 348.76

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	348.76
XLogP3	2.4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	348.1013983
Monoisotopic Mass	348.1013983
Topological Polar Surface Area	104 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	397
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
2315-5	AZD1480
A10110-25	AZD1480 25mg
A10110-50	AZD1480 50mg
A10110-10	AZD1480 10mg
A10110-200	AZD1480 200mg
A10110-100	AZD1480 100mg
A10110-5	AZD1480 5mg
A10110-10mM-D	AZD1480 10mM * 1mL in DMSO
441975-01	AZD1480 discontinued. See 169614

AZD1480

Chemical Information

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