AZD1208

CAT: 0957-S7104-01Size: 10 mgDry Ice: YesHazardous: No

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CAT#:0957-S7104-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. AZD1208 induces autophagy, cell cycle arrest and apoptosis. Phase 1.

CAS Number

1204144-28-4

Target

Pim

Activity

JAK/STAT

Molecular Formula

C21H21N3O2S

Storage Conditions

2 years -80 in solvent

Chemical Information

Azd-1208

CAS Number	1204144-28-4
PubChem CID	58423153
IUPAC Name	(5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione
Molecular Formula	C21H21N3O2S
Molecular Weight	379.5
XLogP	3.6
Topological Polar Surface Area	101
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	27
Formal Charge	0
Complexity	602

SMILES

C1C[C@H](CN(C1)C2=C(C=CC=C2C3=CC=CC=C3)/C=C\4/C(=O)NC(=O)S4)N

InChI

InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1

InChIKey

MCUJKPPARUPFJM-UWCCDQBKSA-N

Chemical Structure

2D Structure

CAS: 1204144-28-4

CID: 58423153

Formula: C21H21N3O2S

MW: 379.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	379.5
XLogP3	3.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	379.13544809
Monoisotopic Mass	379.13544809
Topological Polar Surface Area	101 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	602
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Catalog	Name
A3962-25	AZD1208

AZD1208

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