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Ruxolitinib Phosphate

CAT: 0957-S5243-01Size: 25 mgDry Ice: YesHazardous: No
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CAT#:0957-S5243-01Size:25 mg
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Description
Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.
CAS Number
1092939-17-7
Synonyms
INCB018424, INC424
Target
JAK
Activity
Angiogenesis
Molecular Formula
C17H18N6.H3O4P
Storage Conditions
2 years -80 in solvent

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