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SAR-20347

CAT: 0957-S0437-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-S0437-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SAR-20347 is a potent inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50 of 0.6 nM, 23 nM, 26 nM and 41 nM, respectively. SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling.
CAS Number
1450881-55-6
Target
JAK
Activity
Angiogenesis
Molecular Formula
C21H18ClFN4O4
Storage Conditions
3 years -20°C powder

Chemical Information

2-(2-Chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide
CAS Number1450881-55-6
PubChem CID71727668
IUPAC Name2-(2-chloro-6-fluorophenyl)-5-[4-(morpholine-4-carbonyl)anilino]-1,3-oxazole-4-carboxamide
Molecular FormulaC21H18ClFN4O4
Molecular Weight444.8
XLogP3.5
Topological Polar Surface Area111
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity645
SMILES
C1COCCN1C(=O)C2=CC=C(C=C2)NC3=C(N=C(O3)C4=C(C=CC=C4Cl)F)C(=O)N
InChI
InChI=1S/C21H18ClFN4O4/c22-14-2-1-3-15(23)16(14)19-26-17(18(24)28)20(31-19)25-13-6-4-12(5-7-13)21(29)27-8-10-30-11-9-27/h1-7,25H,8-11H2,(H2,24,28)
InChIKey
HEDPDFHTQKEORT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-Chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide
CAS: 1450881-55-6
CID: 71727668
Formula: C21H18ClFN4O4
MW: 444.8
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight444.8
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass444.1000609
Monoisotopic Mass444.1000609
Topological Polar Surface Area111 Ų
Heavy Atom Count31
Formal Charge0
Complexity645
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-100895-01SAR-20347
HY-100895RSAR-20347 (Standard)
A20380-100SAR-20347 100mg
A20380-50SAR-20347 50mg
A20380-10SAR-20347 10mg

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