BMS-309403

CAT: 0498-bs-83413C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-83413C-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BMS-309403 is a potent (Ki <2 nM FABP4, Ki = 250 nM FABP3, Ki = 350 nM FABP5) and selective inhibitor of the fatty-acid-binding protein aP2 (FABP4) .1,2 It demonstrated marked reductions in atherosclerotic lesions in an Apoe-/- mouse model and improved glucose metabolism, reduced inflammation, and increased insulin sensitivity in a Lepob/ob mouse model. BMS-309403 stimulated glucose uptake in myotubes via activation of AMPK.3 It decreased ER stress-associated inflammation in skeletal muscle4 and suppressed inflammation and oxidative stress in mouse and cell models of acute lung injury5.
Conjugation
Unconjugated
Buffer
Off-white or pale yellow solid
Storage Conditions
-20°C

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GW9859-25mgBMS-309403
B7794-10BMS 309403
MBS5806025BMS-309403 sodium
HY-101903A-01BMS-309403 (sodium)
HY-101903R-01BMS-309403 (Standard)
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