Metformin HCl

CAT: 0498-bs-83305C-01Size: 5 gDry Ice: NoHazardous: No

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CAT#:0498-bs-83305C-01Size:5 g

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Background

Clinically useful antidiabetic agent. Lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis by activation of the AMP-activated protein kinase (AMPK) pathway.1,2 Displays antiproliferative and pro-apoptotic actions in a variety of cancer cell lines.3,4 Induces autophagy via inhibition of the mTOR pathway. Activates PGC1 and improves mitochondrial dynamics in renal tubular cells.5 Upregulates SIRT1 activity in endothelial cells.6 Neuroprotective and lowers -synuclein phosphorylation in the Parkinson’s disease MPTP mouse model.7

Conjugation

Unconjugated

Buffer

White solid

Storage Conditions

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Catalog	Name
A4723-50	Metformin

Metformin HCl

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